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Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients

Received: 20 June 2013     Published: 10 August 2013
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Abstract

Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected, and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.

Published in Cancer Research Journal (Volume 1, Issue 2)
DOI 10.11648/j.crj.20130102.12
Page(s) 20-25
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Gastric cancer, Prognosis, HER 2, Chemotherapy, Docetaxel, Cisplatin

References
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Cite This Article
  • APA Style

    Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, et al. (2013). Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Research Journal, 1(2), 20-25. https://doi.org/10.11648/j.crj.20130102.12

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    ACS Style

    Mustafa Yıldırım; Arsenal Sezgin; Utku Dönem Dilli; Dinc Süren; Mustafa Yıldız, et al. Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Res. J. 2013, 1(2), 20-25. doi: 10.11648/j.crj.20130102.12

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    AMA Style

    Mustafa Yıldırım, Arsenal Sezgin, Utku Dönem Dilli, Dinc Süren, Mustafa Yıldız, et al. Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients. Cancer Res J. 2013;1(2):20-25. doi: 10.11648/j.crj.20130102.12

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  • @article{10.11648/j.crj.20130102.12,
      author = {Mustafa Yıldırım and Arsenal Sezgin and Utku Dönem Dilli and Dinc Süren and Mustafa Yıldız and Vildan Kaya and Cem Sezer and Nurullah Bülbüller},
      title = {Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients},
      journal = {Cancer Research Journal},
      volume = {1},
      number = {2},
      pages = {20-25},
      doi = {10.11648/j.crj.20130102.12},
      url = {https://doi.org/10.11648/j.crj.20130102.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20130102.12},
      abstract = {Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected,  and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.},
     year = {2013}
    }
    

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  • TY  - JOUR
    T1  - Prognostic and Predictive Role of HER2 Expression in Metastatic Gastric Cancer in Turkish Patients
    AU  - Mustafa Yıldırım
    AU  - Arsenal Sezgin
    AU  - Utku Dönem Dilli
    AU  - Dinc Süren
    AU  - Mustafa Yıldız
    AU  - Vildan Kaya
    AU  - Cem Sezer
    AU  - Nurullah Bülbüller
    Y1  - 2013/08/10
    PY  - 2013
    N1  - https://doi.org/10.11648/j.crj.20130102.12
    DO  - 10.11648/j.crj.20130102.12
    T2  - Cancer Research Journal
    JF  - Cancer Research Journal
    JO  - Cancer Research Journal
    SP  - 20
    EP  - 25
    PB  - Science Publishing Group
    SN  - 2330-8214
    UR  - https://doi.org/10.11648/j.crj.20130102.12
    AB  - Background: In this study, we investigate the role of HER2 expression in prediction of the response to treatment combination including dosetaxel, cisplatin and 5-FU which is used in metastatic gastric cancer in Turkish patients. Methods: Patients who were histopathologically diagnosed with metastatic gastric cancer at the Antalya Training and Research Hospital, Clinic of Medical Oncology from 2008 to 2010 were included in this study. Results: IHC assessment identified 4 patients (25%) 0 / negative, 5 patients (31.3%) 1+ / negative, 4 patients (25%) 2 + / suspected,  and 3 patients (18.8%) 3 + / positive. The relationship between HER2 expression and the response using chi-square test was not statistically significant. Conclusions: We believe that identification of patients who will respond to chemoterapy combination is important to prevent complications. The important shortcomings in our study include covering a small number of patients and the use of FISH method. Therefore, we believe that further studies using FISH method with more patients are required to investigate the role of HER2 expression in predicting the response to DCF chemotherapy combination.
    VL  - 1
    IS  - 2
    ER  - 

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Author Information
  • Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey

  • Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey

  • Süleyman Demirel University School of Medicine, Department of Radiation Oncology, Isparta, Turkey

  • Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey

  • Antalya Education and Research Hospital, Department of General Surgery, Antalya, Turkey

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